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These findings highlight the potential of CuO/Al₂O₃ nanocomposite coatings to function as dual-purpose orthopedic implants by leveraging the antimicrobial and osteogenic properties of CuO morphologies. Evaluate the antimicrobial, bioactivity and in vitro cytotoxicity of the nanocomposite CuO/Al2O3 with two different morphologies of copper oxide, which was made with Spark Plasma Sintering (SPS) process on titanium substrate as an orthopedic implant. This innovation addresses critical challenges in implant technology, paving the way for safer and more effective biomedical solutions.