A. Ghaffari , N. Nasserifar ,
Volume 5, Issue 3 (9-2009)
Abstract
In this paper a new mathematical model is developed for the dynamics between tumor cells, normal cells, immune cells, chemotherapy drug concentration and drug toxicity. Then, the theorem of Lyapunov stability is applied to design treatment strategies for drug protocols that ensure a desired rate of tumor cell kill and push the system to the area with smaller tumor cells. Using of this theorem a condition for drug administration to patients so that solution of the system of equations always tends to tumor free equilibrium point is proposed.
V. Ghaffari,
Volume 15, Issue 4 (12-2019)
Abstract
In this paper, a chattering-free sliding-mode control is mainly proposed in a second-order discrete-time system. For achieving this purpose, firstly, a suitable control law would be derived by using the discrete-time Lyapunov stability theory and the sliding-mode concept. Then the input constraint is taken into account as a saturation function in the proposed control law. In order to guarantee the closed-loop system stability, a sufficient stability condition would be addressed in the presence of unstructured uncertainties. Hence the states of the discrete-time system are moved to a predefined sliding surface in a finite sampling time. Then the system states are asymptotically converged to the origin through the sliding line. The suggested SMC is successfully applied in two discrete-time systems (i.e. regulation and tracking problems). The effectiveness of the proposed method will be verified via numerical examples.
